The abdomen houses various organs and is divided into several regions for descriptive purposes. It is important to note that the abdomen does not contain what is typically referred to as "potential spaces". Rather, it contains actual spaces and cavities which are filled with organs and tissues. Let's break down the structure and physiology of these spaces:

Peritoneal Cavity: This is the largest cavity in the abdomen, containing the majority of the abdominal organs. It's a potential space between the parietal peritoneum (lining the abdominal wall) and the visceral peritoneum (covering the organs). Normally, it contains only a small amount of peritoneal fluid for lubrication, but it can potentially expand in pathological conditions like ascites.

The peritoneal cavity is a complex structure located within the abdomen, surrounded and protected by the abdominal wall. It is formed by two layers of peritoneum: the parietal peritoneum and the visceral peritoneum.

1. Parietal Peritoneum: This is the outer layer that lines the inner surface of the abdominal wall and pelvic cavity. It's sensitive to pain, pressure, and temperature, which is crucial in the perception of abdominal discomfort or pain.
2. Visceral Peritoneum: This is the inner layer that folds back onto the organs, covering their surfaces and constituting their serosa. Unlike the parietal peritoneum, the visceral peritoneum is sensitive to stretch and bile salts but insensitive to somatic stimuli like temperature, touch, and cutting.

These two layers form a closed, sac-like structure in males. In females, it's not completely closed because the fallopian tubes open into the peritoneal cavity.

The space between these two peritoneal layers is the peritoneal cavity, technically a potential space because it's usually collapsed, containing a thin layer of serous fluid (about 50 mL in humans) for lubrication. This lubrication facilitates the smooth, frictionless movement of the abdominal and pelvic organs that are covered by the peritoneum.

This cavity extends from the diaphragm in the upper abdomen down into the pelvis. The potential volume of this space is larger than its usual volume because it can be distended under pathological conditions. For instance, in ascites, the peritoneal cavity can hold several liters of fluid that accumulate due to liver disease, malignancy, heart failure, or other conditions. This fluid buildup can cause the abdomen to become noticeably swollen.

Peritoneal folds, which are double layers of peritoneum, extend into the peritoneal cavity and connect organs to each other or to the abdominal wall. These include structures like the greater omentum, lesser omentum, mesentery, and various ligaments. These folds contain blood vessels, lymphatics, and nerves supplying the organs.

Lastly, the peritoneal cavity is involved in immunity as well. The peritoneal fluid contains antibodies, and the peritoneum itself has macrophages, which are cells involved in detecting and destroying harmful bacteria. These components help to prevent and control peritoneal infections.

Retroperitoneal Space: This is a space in the abdominal cavity behind (retro) the peritoneum. It contains organs that are deemed retroperitoneal, such as the kidneys, adrenal glands, pancreas, duodenum parts 2-4, ascending and descending colon, rectum, and the majority of the abdominal aorta and IVC.

The retroperitoneal space, as its name suggests, is the anatomical space in the abdominal cavity behind (retro) the peritoneum. This space is posterior to the parietal peritoneum and anterior to the posterior abdominal wall.

Here's a more detailed look at what it contains:

1. Primary Retroperitoneal Organs: These are organs that were originally formed in the retroperitoneal space and have remained there throughout development. These include the kidneys, adrenal glands, aorta, inferior vena cava (IVC), and certain parts of the gastrointestinal tract like the duodenum parts 2-4 and rectum.
2. Secondary Retroperitoneal Organs: These are organs that were initially formed within the peritoneum during embryological development but migrated to a retroperitoneal position as they grew and developed. These include the pancreas (except the tail), ascending colon, and descending colon.

The Kidneys and Adrenal Glands are key organs situated in the retroperitoneal space. The kidneys play a vital role in blood filtration, fluid-electrolyte balance, and acid-base homeostasis. Each kidney is surrounded by a capsule and adipose tissue, which helps to protect it and hold it in place. The adrenal glands, which are situated atop the kidneys, secrete various hormones that are integral to the body's response to stress, metabolism, and blood pressure regulation.

The Pancreas, a mixed exocrine and endocrine gland, is another important organ in this space. It produces digestive enzymes that are released into the duodenum and hormones such as insulin and glucagon that regulate blood glucose levels.

The Ascending and Descending Colon are parts of the large intestine that absorb water and electrolytes from partially digested food (chyme). Their positioning in the retroperitoneal space allows for continuity in the digestive tract and close proximity to other digestive organs.

Lastly, the Abdominal Aorta and Inferior Vena Cava (IVC), the two major blood vessels in the abdomen, are located in the retroperitoneal space. The abdominal aorta supplies oxygenated blood to the organs in the abdomen, while the IVC returns deoxygenated blood from the lower half of the body to the heart.

The retroperitoneal space's anatomy and the structures it contains are crucial for surgical planning and understanding certain pathological processes, like the spread of disease or pain referral patterns.

Subperitoneal Space: This space is located beneath the peritoneum and includes the urinary bladder, uterus (in females), and the sigmoid colon.

The term "subperitoneal space" is typically used in a radiological context to refer to the anatomic space beneath or under the peritoneum. It includes certain structures and organs that lie under the cover of the peritoneum but are not necessarily within the peritoneal cavity itself.

Here's more information about the organs residing in this space:

1. Urinary Bladder: This organ functions to store urine until micturition (urination) occurs. It is located in the pelvic cavity, posterior to the pubic symphysis. In males, it is located anterior to the rectum, and in females, it is anterior to the uterus and posterior to the pubic symphysis. Its location and association with the peritoneum can vary depending on the degree of bladder distension. When empty or moderately filled, it is located within the pelvis and is covered superiorly by peritoneum. However, when overly distended, it can rise into the abdominal cavity and push the peritoneum superiorly.
2. Uterus (in females): The uterus, part of the female reproductive system, is a pear-shaped organ where fetal development occurs. It is located between the bladder and rectum. The peritoneum covers the superior part of the uterus (fundus and part of the body) and extends onto the bladder, forming the vesicouterine pouch, and onto the rectum, forming the rectouterine pouch or pouch of Douglas. These pouches represent the lowest points of the peritoneal cavity in females.
3. Sigmoid Colon: This is the last segment of the colon before the rectum and is responsible for the storage and movement of feces. It is attached to the posterior pelvic wall by the sigmoid mesocolon, a double layer of peritoneum.

The importance of the subperitoneal space lies not only in the essential functions of the organs it contains but also in understanding certain pathologies and guiding surgical interventions. For example, understanding the connection between the uterus and peritoneal cavity helps to explain the spread of infection or cancer cells. Similarly, appreciating the relationship between the bladder and peritoneum can aid in surgical planning, like in procedures for bladder enlargement or repair.

Intraperitoneal Space: This space is enveloped by peritoneum and includes organs like the liver, stomach, spleen, ileum, jejunum, transverse colon, and sigmoid colon.

The term "intraperitoneal space" refers to the space within the abdominal cavity that is enveloped by peritoneum. Organs in this space are called intraperitoneal organs. They are almost completely encased in peritoneum and are connected to the posterior abdominal wall by a double layer of peritoneum known as a mesentery.

Here's a more detailed look at the intraperitoneal organs:

1. Liver: The largest gland in the body, the liver performs numerous functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion. It is located in the right upper quadrant of the abdomen, below the diaphragm. The liver is connected to the anterior abdominal wall and diaphragm by the coronary and triangular ligaments, which are part of the parietal peritoneum. It's also connected to the stomach by the lesser omentum and to the diaphragm and anterior abdominal wall by the falciform ligament.
2. Stomach: Located in the left upper quadrant of the abdomen, the stomach serves as a major part of the digestive system by producing gastric juices to break down food and moving the partially digested food (chyme) into the small intestine.
3. Spleen: The spleen is involved in filtering blood, recycling red blood cells, and contributing to the immune system. It's situated in the left upper quadrant of the abdomen, lateral to the stomach.
4. Ileum and Jejunum: These are the second and third portions of the small intestine, respectively. They are responsible for the absorption of nutrients from the chyme that has been passed from the stomach.
5. Transverse and Sigmoid Colon: The transverse colon is the longest and most movable part of the colon, and it passes horizontally across the abdominal cavity from right to left towards the spleen. The sigmoid colon is the last part of the colon before the rectum and is responsible for the storage and movement of feces.

Each of these intraperitoneal organs is wrapped in visceral peritoneum, which allows for mobility within the abdominal cavity while providing nerve supply and lymphatic drainage.

Understanding the anatomy of the intraperitoneal space and its organs is key in diagnosing and treating abdominal diseases, as well as planning surgeries and other therapeutic procedures. Any disease process that inflames the peritoneum (such as appendicitis or peritonitis) can result in severe abdominal pain and other symptoms. Moreover, certain pathological conditions can cause fluid, air, or blood to accumulate within this space.

Physiology: These spaces play crucial roles in the functioning of the abdomen. The peritoneal cavity, with its small amount of lubricating fluid, allows for the smooth, frictionless movement of the abdominal organs. Meanwhile, the positioning of the organs within the different spaces (retroperitoneal, subperitoneal, and intraperitoneal) allows for the appropriate connections to blood vessels and nerves, the organized transit of digested food, and the functional relationships between different organs.

Each organ within these spaces carries out its unique function, contributing to the overall homeostasis of the body. For example, the liver processes nutrients absorbed from the small intestine and synthesizes proteins important for blood clotting, among many other functions. The kidneys in the retroperitoneal space filter blood and eliminate waste products through urine, etc.

Any abnormalities in these spaces, such as fluid buildup (ascites) or the presence of air (pneumoperitoneum), can suggest disease and can impact the function of the contained organs. These abnormalities can often be detected via imaging techniques like ultrasound or CT scans.