Epigenetics refers to changes in gene expression that do not involve alterations to the underlying DNA sequence. Epigenetic changes can be influenced by various factors, including environmental exposures, age, and disease state. They involve modifications to the DNA...
Fibrosis is a pathological process characterized by the excessive accumulation of extracellular matrix (ECM) components, particularly collagen, leading to the thickening and scarring of tissues. It can occur in response to chronic inflammation or injury and can affect...
Cellular senescence is a state of permanent cell cycle arrest, meaning the cell can no longer divide and proliferate. It's a complex process that can be triggered by a variety of factors, including DNA damage, oxidative stress, telomere shortening, and oncogenic...
The extracellular matrix (ECM) is a three-dimensional network of extracellular macromolecules such as collagen, enzymes, and glycoproteins that provide structural and biochemical support to surrounding cells. It plays a critical role in tissue and organ morphogenesis...
Tissue fibrosis involves the excessive deposition of extracellular matrix (ECM) proteins, predominantly collagen, which can disrupt normal tissue architecture and function. This pathological remodeling can also significantly impact interstitial fluid dynamics and...
